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Related post: technology, for example, already has supplied a variety of clinically useful reagents. The OKT series of monoclonal antibodies can effectively distinguish human peripheral blood lymphocytes on a functional or differentiated basis. Human helper and suppressor T lymphocytes can be distinquished with these antibodies and they have been employed in the clinical diagnosis of various immunologic disorders. Acute lymphoblastic leukemias have been characterized on the basis of differential expression of OKT-defined antigens and abnormal levels of T cell subpopulatlons have been detected in patients with multiple sclerosis and systemic lupus 5-8 erythematosus as well as in AIDS patients. Promising results with the Buy Ayurslim use of monoclonal antibodies against influenza and rabies viruses have been found to detect serologic differences between isolates which were indistinguishable by by previously available diagnostic antisera. Monoclonal anti-rabies antibodies have been demonstrated to be dramatically effective in protecting mice from lethal infections. Rapid, precise, and semi-automated diagnosis of human sexually transmitted diseases using monoclonal antibodies against gonococci, Chlamidia, and herpes viruses will soon be readily available. It is reasonable to expect that in the near future, applications of hybridoraa technology for clinical diagnosis will be extensive and will offer extremely useful approaches to therapy of a variety of immunologic, infectious, and neoplastic diseases. 5-9 Microbiology and Infectious Diseases Program 1983 Annual Report Table of Contents Report of the Director ^"1 A. Administrative Svunmary 5-1 B. Scientific Summary 5-3 C. International Health 5-10 Bacteriology and Virology Branch 7-1 A. Bacteriology 7-2 Sexually Transmitted Diseases 7-2 Streptococcal Diseases and Sequelae 7-3 Hospital Associated Infections 7-4 Cystic Fibrosis 7-5 Legionnaires' Disease 7-5 Staphylococcal Infections 7-5 Basic Research 7-6 Leprosy 7-7 Tuberculosis 7-7 B . Mycology 7-8 C . Virology 7-8 Clinical and Epidemiological Studies Branch 8-1 A. Enteric Diseases Program 8-1 B. Closed Volunteer Facility 8-3 C. Collaborative Clinical Trials of Antibiotic Therapy 8-5 D . Nutrition , Infection and Immunity 8-7 E. Rapid Viral Diagnosis 8-7 F . Acquired Immunodeficiency Syndrome 8-8 G . Epidemiology and Biometry Section 8-9 H. Infectious Diseases 8-9 I . Immunologic Diseases 8-10 J, Biometric Consultation and Research 8-10 K. Other Activities 8-11 Development and Applications Branch 9-1 A. Introduction 9-2 B . Program Summary 9-2 C. Influenza Program 9-4 D. Viral Respiratory Diseases Program 9-5 E. Viral Hepatitis Program 9-6 F. Antiviral Substances Program 9-7 G. Bacterial Vaccines Program 9-9 Pneumococcal Diseases 9-9 Meningitis 9-10 Pertussis 9-1 1 H. Viral Vaccine Program 9-11 Molecular Microbiology and Parasitology Branch 10-1 A. Introduction and Staff Activities 10-1 B. Molecular Microbiology 10-2 Mechanisms of Resistance to Antimicrobial Agents 10-3 Recombinant DNA Molecular Research 10-4 Other Basic Research 10-5 C. Parasitology 10-6 Biological Regulation of Vectors 10-7 Immunology of Parasitic Infections 10-8 General Parasitology Research Highlights 10-10 Contract Activity 10-10 ii Microbiology and Infectious Diseases Program Annual Report, 1982-83 Director's Report Administrative Summary Function and Organization : The Microbiology and Infectious Diseases Program (MIDP) supports research with the broad aim of improving health by controlling diseases caused by infectious or parasitic agents. During FY 1982-83, MIDP operated with the following organizational structure and staff. Office of the Director (OD) Director-William S. Jordan, Jr., M.D. Special Assistant to the Director (International Health)-Earl S. Beck, Ph.D. Bacteriology and Virology Branch (BVB) Chief-Milton Puziss, Ph.D. Virology Program Officer-William P. Allen, Ph.D. Mycobacteriology and Buy Ayurslim Online Mycology Program Of f icer-Darrel Gwinn, Ph.D. Clinical and Epidemiological Studies Branch (CESB) Chief-Robert Edelman, M.D.
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